Mice lacking Asic3 show reduced anxiety-like behavior on the elevated plus maze and reduced aggression
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منابع مشابه
Modulation of Anxiety-Like Behavior in Sildenafil Citrate-Treated Mice Placed in an Elevated Plus-Maze
Introduction: Sildenafil, a phosphodiesterase-5 (PDE5) inhibitor, may have various effects on the central nervous system via the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway. Preclinical studies have shown the controversial effect of sildenafil on anxiety-like behavior in animals. This study was undertaken to investigate the acute effect of sildenafil on anxiety-like behavior...
متن کاملmodulation of anxiety-like behavior in sildenafil citrate-treated mice placed in an elevated plus-maze
introduction: sildenafil, a phosphodiesterase-5 (pde5) inhibitor, may have various effects on the central nervous system via the nitric oxide (no)-cyclic guanosine monophosphate (cgmp) pathway. preclinical studies have shown the controversial effect of sildenafil on anxiety-like behavior in animals. this study was undertaken to investigate the acute effect of sildenafil on anxiety-like behavior...
متن کاملModulation of Anxiety-Like Behavior in Sildenafil Citrate-Treated Mice Placed in an Elevated Plus-Maze
smooth muscles, and therefore, improved erection (McCullough, 2002; Ulhayathas et al., 2007). Evidence shows that sildenafil inhibits cGMP degradation in the brain (Hotchkiss et al., 2005; Riazi et al., 2006) and affects the central nervous system (Ulhayathas et al., 2007). In the NO-cGMP pathway, sildenafil modulates cognition, memory, reward-related stimuli, pain perception, seizure attack, n...
متن کاملEthological and temporal analyses of anxiety-like behavior: the elevated plus-maze model 20 years on.
As well as being considered a reliable measurement instrument of animal anxiety-like behavior, the elevated plus-maze (EPM) is also used as a post-hoc test to evaluate emotionality in genetically modified rodents. The present review considers factors which may further improve the validity (predictive/face/construct) of the EPM model: (1) the importance of measuring defensive patterns of respons...
متن کاملEffect of inhalation alcoholic extract of Peganum harmala on induction of Anxiety like behavior in Elevated Plus-Maze
Based on the extensive application of Peganum harmala (P.h) seeds in the Asian traditional medicine, we tried to investigate its possible anxiety effect. Method: The effect of P.h. extract inhalation was evaluated in adult male rats using elevated plus-maze apparatus. The humidity of prepared ethanol extract was 37%. Animals in different groups (n=6) received 2, 4, 6, 12 or 18 gr/ml doses of...
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ژورنال
عنوان ژورنال: Genes, Brain and Behavior
سال: 2010
ISSN: 1601-1848,1601-183X
DOI: 10.1111/j.1601-183x.2010.00591.x